Mineralys Therapeutics (MLYS) 11 Nov 242024 Q3 Earnings call transcript

Greetings. Welcome to Mineralys Third quarter 2024 Financial Results Conference Call. [Operator Instructions].

As a reminder, this conference is being recorded.

It is now my pleasure to introduce Dan Ferry of LifeSci Advisors. Please begin.

Thank you, operator. Good afternoon, everyone, and welcome to our third quarter 2024 conference call. After the close of market trading today, we issued a press release providing our third quarter 2024 financial results and business updates. A replay of today's call will be available on the Investors section of our website approximately 1 hour after its completion. After our prepared remarks, we will open the call for Q&A.

Before we begin, I would like to remind everyone that this conference call and webcast will contain forward-looking statements about the company. Actual results could differ materially from those stated or implied by these forward-looking statements due to risks and uncertainties associated with the company's business. These forward-looking statements are qualified by the cautionary statements contained in today's press release in our SEC filings, including our annual report on Form 10-K and subsequent filings. Please note that these forward-looking statements reflect our opinions only as of today, November 11, except as required by law, we specifically disclaim any obligation to update or revise these forward-looking statements in light of new information or future events.

I would now like to turn the call over to Jon Congleton, Chief Executive Officer of Minerals Therapeutics. Jon?

Thank you, Dan. Good afternoon, everyone, and welcome to our third quarter 2024 Financial Results and Corporate Update Conference Call. I'm joined today by Adam Levy, our Chief Financial Officer; and Dr. David Rodman, our Chief Medical Officer. I'll begin with an overview of the business, our clinical programs and recent milestones. Then Adam will review our third quarter financial results before we open up the call for your questions.

I want to kick things off with a recap of the progress the Mineralys team has made these past several months, advancing our pivotal clinical development of lorundrostat in hypertension and then discuss the upcoming milestones we anticipate throughout the first half of 2025. We recently completed enrollment in our pivotal Advance HTN trial, which is evaluating the efficacy and safety of lorundrostat for the treatment of uncontrolled or resistant hypertension. When used as an add-on therapy to a standardized background treatment of 2 or 3 antihypertensive medications.

Subjects were randomized across 3 arms, including placebo, lorundrostat 50 milligrams once daily, or lorundrostat at 50 milligrams once daily with the possibility to titrate up to 100 milligrams once daily. We announced the key characteristics of subjects and roll in trial include more than 66% of the subjects have a BMI equal to or greater than 30, more than 40% of the subjects are women and more than 50% of the subjects are black or African American race.

Notably, in terms of demographics, we took extra steps to broaden the diversity of the subjects in this trial to provide a better representation across different populations with the goal of showing equivalency across race and sex.

As a reminder, this trial was designed in collaboration with the Cleveland Clinic based on the most rigorous standards. The trial will be utilizing 24-hour ambulatory blood pressure monitoring or 24-hour ABPM, which is the gold standard for blood pressure measurement and historically has shown lower rates of white coat hypertension and has better managed placebo responses compared to other measurement approaches.

Additionally, 24-hour ABPM has the ability to assess nighttime blood pressure and nighttime blood pressure dipping status, which have been shown to play a role in adverse cardiovascular risk and outcomes. Advance-HTN is utilizing smartphone-based technology to track and manage participant compliance to lorundrostat with a partner called AiCure, which helps ensure that participants take all medication as prescribed under the trial protocol.

The primary endpoint for this trial is change in 24-hour ambulatory systolic blood pressure at week 12 from baseline for active cohorts versus placebo. The planned analysis includes several important subset analysis in an effort to identify predictors of enhanced response to lorundrostat, such as obesity that was demonstrated in the Phase II Target-HTN trial. Subjects with uncontrolled or resistant hypertension were stratified providing balanced distribution across each of the 3 arms of the trial to allow us to perform a formal test in each population.

We believe demonstrating robust efficacy and confirmed resistant hypertension, the area of highest unmet medical need will be important in positioning lorundrostat for rapid access and uptake by payers and physicians. Positioning lorundrostat for obese uncontrolled hypertension patients who are at increased cardiovascular risk will provide an expanded market opportunity.

In addition, as we accrue more experience and data with lorundrostat, we plan to continue to explore other positive and negative predictive factors including using artificial intelligence to expand the precision toolkit for targeting lorundrostat to individuals with uncontrolled or resistant hypertension who are likely to drive long-term clinical benefit. We look forward to announcing the top line data, which we anticipate sharing in March of 2025.

Moving to Launch-HTN, our second pivotal trial, which is designed to be a confirmatory trial with the objective of evaluating lorundrostat in a real-world setting when added to a subject's previously prescribed in a hypertension regimen. We were excited to announce just a few weeks ago that we completed enrollment in this trial. With enrollment of Launch-HTN completed ahead of schedule, we updated our guidance for top line data pulling these results forward to mid-first half 2025. Launch HTN is a Phase III trial of lorundrostat for the treatment of subjects with uncontrolled or resistant hypertension as add-on therapy who failed to achieve blood pressure control on their existing prescribed background treatment of 2 to 5 in hypertensive medications. Subjects enrolled in the trial who failed to achieve blood pressure control on their existing prescribed treatment were randomized 1 to 2 to 1 to either placebo, once daily 50 milligrams of lorundrostat or once daily 50 milligrams of lorundrostat with the option to titrate 100 milligrams once daily as needed at week 6.

The primary endpoint for this trial will be the change in systolic blood pressure as measured by automated office blood pressure at week 6 for the pooled 50-milligram subjects compared to placebo. This trial is well powered at 6 weeks for the primary endpoint as well as subset analysis such as BMI status to inform the clinical label of lorundrostat. We believe this trial is reflective of clinical practice utilizing the real-world in-office measurement and when lorundrostat is added to an existing treatment regimen that will be relevant to primary care providers.

In addition to our pivotal program in hypertension, we are connecting the Explore CKD Phase II clinical trial for lorundrostat lorundostat when added to background treatment with SGLT2 inhibitor in patients with uncontrolled or resistant hypertension, in Stage II to III chronic kidney disease. Enrollment is ongoing, and we anticipate announcing top line data in the second quarter of 2025.

Explore CKD as a within-subject comparison trial designed to demonstrate the benefit of lorundrostat in reducing blood pressure and provide supportive evidence for potential benefit for subjects with chronic kidney disease on the background of stabilized GLT2 inhibitor treatment. This proof-of-concept trial will enroll approximately 60 subjects with hypertension in stage II to III CKD.

Before I turn the call over to Adam, I just want to remind everyone that a replay of the KOL event, we hosted on October 30 is still available on the Investors section of the Mineralys website.

We are very fortunate to have 3 leaders in the hypertension field join us on the call, including Dr. Luke Lofton of the Cleveland Clinic; Dr. James Luther of Vanderbilt University Medical Center, and Professor Rhian Touyz of McGill University Health Center. Be offered valuable insights on the unmet medical need and uncontrolled and resistant hypertension as well as the potential for lorundrostat to change the current treatment paradigm.

We also included a detailed review of the ongoing Advance HTN and Launch HTN pivotal trials and their designs.

I will now turn the call over to Adam to review our financial results for the quarter.

Thank you, John. Good afternoon, everyone. Today, I will discuss select portions of our third quarter 2024 financial results.

Additional details can be found in our Form 10-Q, which will be filed with the SEC tomorrow November 12. We ended the quarter with cash, cash equivalents and investments of $263.6 million as of September 30, 2024, compared to $239 million as of December 31, 2023. The company believes that its current cash, cash equivalents and investments will be sufficient to fund its planned clinical trials as well as support corporate operations into 2026.

R&D expenses for the quarter ended September 30, 2024, were $54 million compared to $22.5 million for the same quarter of 2023. The increase in R&D expenses was primarily due to increases of $26.1 million in preclinical and clinical costs driven by the initiation of the lorundrostat pivotal program in the second quarter of 2023, $3.4 million in clinical supply, manufacturing and regulatory costs, $1.7 million in higher compensation expense as resulting from additions to headcount, increases in salaries and accrued bonuses and increased stock-based compensation of $0.3 million in other research and development expenses.

G&A expenses were $6.1 million for the quarter ended September 30, 2020 compared to $3.8 million for the same quarter of the prior year. The increase in G&A expenses was primarily due to $1.7 million in higher compensation expense resulting from additions to headcount, increases in salaries and accrued bonuses and increased stock-based compensation and $0.8 million in higher professional fees partially offset by a decrease of $0.2 million in other administrative expenses.

Total other income was $3.8 million for the quarter ended September 30, 2024, compared to $3.5 million for the same quarter of 2023. The increase was primarily attributable to increased interest earned on the company's investments in money market funds and U.S. treasuries. Net loss was $56.3 million for the quarter ended September 30, 2024, compared to $22.8 million for the same quarter of 2023. The increase was primarily attributable to the factors I described earlier. With that, I'll ask the operator to open the call for questions. Operator?

[Operator Instructions].

Our first question is from Michael DiFiore with Evercore ISI.

Congrats on all the progress. Three for me.

First one is just in reviewing the Target HTN data set, looking at the nighttime blood pressure results and in the sensitivity analysis, even after the white code hypertension patients were eliminated, you noticed that there wasn't any nocturnal dipping at 8 weeks in the 50-milligram QD group. Any color to explain that would be great. And then I have 2 follow-ups.

Yes.

So this is Dave Rodman. Why don't I take that question.

So first of all, you're absolutely right that the big value driver in 24-hour ambulatory measurements is, first of all, you get a lot of measurements, so you get a much quieter data, a lot less noise. But you also get to segmented into nighttime and daytime, and as you mentioned, night times particularly important because untreated nocturnal hypertension is a big risk factor for adverse cardiovascular outcomes and MACE.

So if I can point you first to the 100-milligram cohort where we had very little white code hypertension, There, the nighttime response to lorundrostat was comparable to what was seen in wakefulness, even though the dose was taken in the morning and those measurements were in the evening.

And so that's what you would expect. The 50-milligram is a little more problematic to interpret because there was a very high proportion of patients who on the ABPM appear to have kind of a lower blood pressure than they had with AOBP or so-called white coat hypertension.

So we had to subtract all those people out to do the sensitivity analysis and when we did that, it was about a 50% reduction compared to daytime.

I think it's unlikely that's true because the numbers got too small. I do think the 100-milligram is probably a better guide post. But in any event, we'll be looking and controlling for that in the trial.

So we'll have the accurate answer for that.

SP-7 Got it, Dave. Very helpful. And my 2 follow-ups are, we're just reviewing the early safety database, like the first-in-human study data set. And I noticed that in the Phase I MAD trial, there was one case of sinus tachycardia at 360 milligrams. And then my question is how big of a safety margin relative to the NOAEL is 315 milligram? And separately, in the same data set, there was also one case of dysgeusia at 40 milligram. And just ask me because that could potentially be an unblinding, a functional unblinding type of thing. Any explanation of those 2 as would be great.

So the first -- well, I'll take the first one first.

So that's a pretty big dose, 360 milligrams. How does this drug work well acutely, and causes volume loss.

So you urinate out sodium and water, the response to that is sinus tachycardia.

So when you get dehydrate or volume depleted, that's what happened.

So it's not really a safety finding. It's a pharmacodynamic effect of a healthy volunteer having too much volume depletion.

And so that we don't expect to read through at the lower doses, especially in these hypertensive patients.

Now your second question, dysgeusia, I got no idea on that one. I just don't know. We didn't haven't seen it again whether it's unblinding or not, it just hasn't been a functional problem in our trials. Anything else, Mike?

No, that's it. Appreciate it.

Our next question is from Richard Law with Goldman Sachs.

A couple of questions from me.

The first one is for Advance, you guys are tracking and proactively enforcing adherence. Can you discuss what is the adherence rate for target HTN? And how much do you think that adherence can improve in Advance HTN?

So the question was what's the adherence rate in the Target HTN trial versus an Advance or...

No, you're looking for what is the goal Rich, can you restate your question again? Sorry.

Yes.

So for Advent, you guys are tracking and proactively enforcing adherence, but you guys are not doing -- you guys didn't do that for target HTN.

So just curious to see what was the adherence rate for target CN -- and how much do you think that could improve as you move into Advanced HTN by proactively tracking and enforcing?

Okay. Got you. Good question.

So -- we didn't -- the only thing we did was really was to do pill counts when people came in to see if they had taken their drug or not. We piloted some technologies, but we didn't really use the data -- that's how we ultimately ended up choosing the AI cure method that we're using now.

So I can't give you any accurate information because pill counts are notorious ineffective because people know you're doing it.

And so they might just dump them in the sink or whatever. But in the launch trial, we are also doing adherence, but we're not actively supporting that in terms of reaching out or telling them much.

And so other than the normal reminders.

So I think there -- and there, we're going to do a subset analysis that looks at your question, which is how much is non-adherence a problem in terms of responses.

So we'll do a sensitivity analysis on people who took more than 75% or not.

So I can't really comment too much on the target, but we will have an answer to your question.

I see. Got it. And then another question.

You guys mentioned a lower absolute SPP value with the ABPM measurement. How do you think about the placebo adjusted ABPM and how would that change compared to placebo and just AOBP, for example, in Advance HTN? Is it safe to assume that both are very similar if the study is well controlled.

Well, I'll give a quick heads up on that, Rich. We typically see with 24-hour ambulatory it's plus or minus 1, maybe 2 millimeters of mercury with a placebo with that 24-hour AOBP, you see a little bit more variability with that because it's in office. It's single time point from a measurement standpoint from Target HTN because of the technique we use in doing 5 measurements and a quiet room unattended and averaging the last 2. We saw about a 4-millimeter mercury change. We know prior studies that have used different methodologies around that, such as the SanCor trials actually saw higher figures than that.

So from our standpoint, following the recommendations from the AHA, we're continuing to repeat our technique for in-office measurement. -- and have not only 24 ambulatories, the primary in advance along within office, we also have in home.

So we have 3 different measures within advanced HT and the in-office practice that we use for launch H1 -- and so we feel confident that we've controlled for the variables within the different techniques. Then we'll -- that's based on the work that we've done with Target HTN.

Rich, one other comment here is that the measurements with ABPM, because they average in nighttime, which tends to be lower in people that don't have say sleep apnea, tend to be about 5 millimeters mercury lower and response to hypertension drugs is proportionate to the level of the baseline blood pressure.

So if you have a lower baseline blood pressure, you have -- you can go down less, so you have a little bit smaller response.

So it's -- so most people say you have 1 or 2 millimeters smaller placebo-adjusted treatment effect when you do ABPM versus AOBP. And then as John mentioned, those numbers are just shifted up with the ABPM, but there's more variability in the placebo effect there.

So they're just a little bit noisier. Maybe that was more than you wanted to know, but just to pass it on.

No, I think that helps a lot.

So you're saying about 5 or so on an absolute basis, but once you adjust for placebo, that should be about 1% to 2%?

Not sure that puts -- so the difference is that with a ABPM because of all the multiple measurements, your placebo effect is going to be pretty small. I would say 1 to 4 is what I've seen in the literature. In a big enough study, it will be one or 2, and that's what we were with our Target study. ABPM, up to 7. I mean, AOBP, sorry, up to 7 millimeters of mercury or even if you look at Baxter set, they had 9, I think, in their first trial, up to 7 acceptable in general, it's in the range. We had 4.

So -- and we put a lot of work into making sure we get the best data we can.

Obviously, when you get to bigger trials and more sites, you tend to have slightly more variability I'm not sure I understood your question per se, but I hope that gives you the answer you needed.

Okay. Got it. And then just one final question.

You guys mentioned greater than 66% patients with BMI greater than 30. What is the power assumption for that, like greater than 30 and less than 30 BMI group from that 66% number.

I think you guys mentioned a 90% powering assumption for the overall group.

So I just want to see what that powering assumption look like when you go down to these prespecified subgroups?

Yes, Rich, thanks for the questions. Advance-HTN overall is 90% power for a 7-millimeter mercury change relative to placebo, Launch-HTN, greater than 95% power for the same reduction. And we haven't disclosed at this point in time any of the subset analysis power calculations.

Our next question is from Annabel Samimy with Stifel.

I just want to clarify a couple of things.

For Advance-HTN, the primary endpoint is at 12 weeks with titration at 4 weeks and then launch has up titration at 6 weeks with the primary endpoint there, but it runs to 12 weeks, if I'm reading your presentation correctly.

So is that -- is the 6 weeks sufficient for that separation given the possible additional noise that might be introduced with real-world background meds. I guess how are you managing the placebo response in that scenario? Are there going to be more confounding results possibly and a 6 weeks sufficient? I guess, why not run it to 12 weeks with that kind of background variability.

Yes, Annabel, appreciate the question.

I think it's important to think of Launch-HTN very much as a confirmatory study to Target-HTN. There are a lot of similarities as far as the construct -- as you know, in Target as in Launch, we allow subjects to stay on their background medication of 2 to 5 antihypertensive treatments.

We have that 2-week run-in period on placebo. When we get them compliant to their existing background meds. We're using AOBP and Launch-HTN, same techniques, same technology that we used in Target. What we saw in Target-HTN was about 70%, plus or minus, of the effect at week 2 and by week 4, the vast majority of the effects.

So we're comfortable that, that 6-week data readout. We're not going to be missing really any significant reduction in blood pressure within that time course just based on what we saw within Target HTN at week 4. And I'll just highlight that maybe one of the biggest distinctions between the 2 studies is we definitely saw a potential synergy with the diuretic in target, where about half the subjects were on a diuretic and by design, both in Advance and in Launch HTN, all subjects are on a diuretic.

So I think we've factored in the profile of arena within this confirmatory design of Launch-HTN that we don't feel we're going to be missing anything. Plus as part of the secondaries, we will be looking at that 12-week time point for both the 50-milligram arm and the 50 upside treated to 100-milligram arm.

Okay. Got it. And just to go back to -- the last question for -- I mean, I know you haven't disclosed a powering for obese versus nonobese, but is there a possibility to see statistical significant separation between the 2?

Well, I think we'll be looking at as we did in Target-HTNand these prespecified subsets in both Advance and in Launch. The primary benefit of moving the primary endpoint of Launch-HTN from week 12 to week 6 was not power for the primary but was power for those subset analysis.

And so we feel very confident that we're going to be able to if the trend reconfirms as we saw on Target HTN, be able to have the statistical power to evidence that. But again, we've got to get to the data but that's going to be part of the prespecified analysis as we didn't target HTN.

Okay. Got it. And then just to also clarify, should we expect any dose response between the 50 and the 100 milligrams arms? Or is this more about getting patients to the right exposure so they can actually have a response as opposed to -- like in other words, should we be looking for dose response should we just be looking for blood pressure control period?

Yes. What a good question.

So 2 ways to look at that. at 12 weeks -- let's just talk about Advance at 12 weeks in Advance, there'll be 3 arms, right? They'll be -- and the same thing is true in Launch. There'll be a placebo group. There'll be a group that stayed on -- and then there'll be a group that got escalated if they hadn't reached goal to 100.

And so if the -- if people didn't have a high enough exposure at 50 because they didn't absorb it well or whatever, 100 might fix that. If people just have a lot of aldosterone production and they aren't completely suppressed at 50 than 100 would fix that.

So we won't know for sure if its exposure to drug or individual biology until we start looking at maybe downstream mechanistic biomarkers, which won't come for a while.

So I hope that answered your question.

You're absolutely right.

Our next question is from Mohit Bansal with Wells Fargo.

This is Sadia on for Mohit.

So you've outlined patient demographics for the Advance trial. I'm wondering if in launch you're targeting similar demographics in terms of the percentage of obese patients and the percentage of African-Americans are -- will they be -- or should we expect differences in any of these? And can you remind us how these rates in Advance compared to the population that was enrolled in target?

Yes.

We haven't updated on the demographics of Launch HTN. We may do that in the future. Target HTN, I believe we had about the BMI average was 31%, mean in Target HTN was 31, what is it kilograms per meter square and Black African-American population, I believe it was around 39%.

So not terribly dissimilar from what we saw in Advance.

I think it's fair to point out that both Advance and Target probably beyond what you typically see as far as representation for Black African-American in that's important to really show equivalency between Caucasian and Black African-American hypertension patients because that's not always the case with all anti-hypertensives.

Sometimes you can see disparity in response. We wanted to be able to evaluate that as a part of our precision tool kit.

As far as launch-HTN, it is a global study. We've gotten questions is that going to dilute the BMI effect.

I think the counterpoint to that is the obesity correlation with hypertension holds pretty strong globally.

And so we don't have a concern that the makeup of Launch-HTN is going to look too terribly dissimilar from what we saw in Target HTN even though it is a global study versus U.S. alone for Target.

Jon, if I could just add one thing, and that was a very nice discussion. There's a difference between African-Americans and Black Africans as well as the European population, which tends to be -- doesn't have the same admixture of hit of the Caucasian genes.

So African-Americans are on the whole super sensitive to aldosterone, lower levels of Alto produce more hypertension. That's not true in Europe.

And so since we have European sites, we are going to have to distinguish between those 2, and we will.

Got it. That's helpful. And then with respect to the number of sites and geographies that are being enrolled in launch versus the other trials, -- how are you thinking about the placebo response and launch? Do you think there could be a higher placebo response? And was that part of your powering assumption for Launch?

So Launch is pretty much super powered because it's such a big study and looking at similar effect size.

So if your question is well, if there's an upward shift from the placebo effect, which presumably would affect both arms, is that going to introduce more variability and, therefore, decrease the power. And the answer is it won't be a significant problem in a trial of that size with the powering it has.

Our next question is from Rami Katkhuda with Lifesci Capital.

Just a couple of quick ones from me. I guess based on the inclusion criteria, Advance and Launch are recruiting patients to a lower eGFR than those in target, does that have the potential to affect hyperkalemia rates at all in the pivotal studies?

You're right, Rami. We looked at 60 GFR and above for target based on that. We were comfortable going down to the 45% for both Launch in advance.

I think it's too early to tell at this point. We'll have to see what the data indicates. But we know from the 50-milligram arm and Target H10, we really saw a modest change in potassium similar to what you would expect with an [indiscernible] arm. The Explore CKD study where we're going down to an eGFR of 30 is allowable. We've actually reduced the dose to 25 milligrams QD.

I think it's within that population that we want to move cautiously as we investigate lorundrostat in both the benefits as well as the safety profile, specifically related to this pharmacological effect on sodium and potassium.

Got it. Makes a lot of sense. And then in launch, obviously, compliance is not being enforced as it is in advanced. Do you plan to do kind of an analysis of those patients who were compliant throughout the trial versus those who are not?

Yes. The technology of AI cure is really -- it's been validated, but it's really just a next-level advancement. And how do we really ensure patients take the drug for those that may not be aware, subjects have to take a picture of not only their background meds, but also either the placebo or the active ones, they're randomized. They also have to film themselves consuming it. That technique and that technology is being used both in advanced launch in advance, we're proactively reaching out to subjects if they're not being compliant and reminding them of the importance of that, as you know, in Launch, we are not, but we are going to prespecify an analysis looking at compliance, I believe it's for those above 75% compliant in those below 75%.

So we'll have that as a prespecified analysis.

So that we can look at that impact. And I think just to build on Dave's point, we saw really nice compliance in Target HTN, but it was with less advanced technologies that are not completely full proof. In other words, pill counts are kind of a standard way to do it, but we know patients can manipulate that. We're progressively trying to use technology to help patients help us with one of the most important things they can do and that is being compliant to the pill.

So I think we're currently using state-of-the-art validated technology to really help ensure that we've addressed one of the bigger questions in these kind of studies that we know has been an issue with other hypertension studies contemporaneously.

Our next question is from Matthew Caufield with H.C. Wainright.

So you kind of touched on this with the power in, but for advanced HTN, during the KOL event, it was mentioned that 6 to 8 millimeters of ambulatory BP benefit could be clinically meaningful. Does that range translate the same to potential target ranges or better for launch and explore to be considered successful?

Yes Matt, I appreciate the call. Yes, I think the KOL call was really instructive because I think they started by highlighting the fact that 1 or 2-millimeter mercury change, particularly in a truly resistant or even uncontrolled hypertension hypertension patient is meaningful as far as reducing cardiovascular risk.

So it's always important to put that into context.

I think the 6 to 8-millimeter that [ Luc ] often alluded to in a broad population is absolutely on point.

There's a clear correlation to reduced risk from an outcome standpoint. Based on the market research we've done with payers and with physicians, that's certainly within the the realm of what's important and transformative for them. We've always guided that, that 8- to 10-millimeter mercury change that we saw in Target HTN if replicated in Advance and within Launch, would be truly meaningful to the market. And that's based on meta-analysis that show with currently available generic treatments when you add a third or fourth line agent, you typically get a 5-millimeter mercury further reduction in systolic.

New advances like renal denervation or [ Apperson,] 1010 have found 4 to 6-millimeter mercury reduction.

So that replication of 8 to 10 is truly meaningful. And if we find subsets such as an obese population that have a more pronounced effect that becomes even more transformative. And ultimately, the goal is getting patients below their prescribed BP goal. And that's something we'll be looking at within both of these studies as well as not only the absolute and placebo-adjusted production, but what is the percent of subjects actually getting to goal and having a foundational shift in their cardiovascular risk profile.

Very helpful. And you would say that applies to explore CKD as well? Yes, I think it does. It certainly does an Explore is not only that benefit from a BP standpoint, but really investigating what we think is now a derisked benefit of an ASI in combination with an SGLT2 on renal function as well.

With no further questions in the queue, I would like to turn the conference back over to Jon for closing remarks.

Thank you, operator, and thank you to everyone for joining us today. We're very excited about the progress we've made thus far in 2024 in advancing our clinical programs, and we remain enthusiastic about the upcoming data milestones planned for the first half of 2025. We look forward to updating you as our pivotal program for Lorundrostat continues to advance. With that, we will close the call.

Thank you. This does conclude today's conference.

You may disconnect at this time, and thank you for your participation.